![]() Every day over 250 grams of protein in your body are dismantled and 250 grams of new protein are built. All cells in the body continually break down proteins and build new ones, a process referred to as protein turnover. Just as some plastics can be recycled to make new products, amino acids are recycled to make new proteins. Because amino acids are building blocks that the body reserves in order to synthesize other proteins, more than 90 percent of the protein ingested does not get broken down further than the amino acid monomers. This makes it a good choice for transporting excess nitrogen out of the body. Urea is a molecule that contains two nitrogens and is highly soluble in water. Because ammonia is toxic, the liver transforms it into urea, which is then transported to the kidney and excreted in the urine. Recall that amino acids contain nitrogen, so further catabolism of amino acids releases nitrogen-containing ammonia. As with other macronutrients, the liver is the checkpoint for amino acid distribution and any further breakdown of amino acids, which is very minimal. Once the amino acids are in the blood, they are transported to the liver. This movement of individual amino acids requires special transport proteins and the cellular energy molecule, adenosine triphosphate (ATP). In the lower parts of the small intestine, the amino acids are transported from the intestinal lumen through the intestinal cells to the blood. The muscle contractions of the small intestine mix and propel the digested proteins to the absorption sites. The cells that line the small intestine release additional enzymes that finally break apart the smaller protein fragments into the individual amino acids. The two major pancreatic enzymes that digest proteins are chymotrypsin and trypsin. The pancreas secretes digestive juice that contains more enzymes that further break down the protein fragments. The stomach empties the chyme containing the broken down egg pieces into the small intestine, where the majority of protein digestion occurs. Food remains in the stomach longer, making you feel full longer. Eating a high-protein meal increases the amount of time required to sufficiently break down the meal in the stomach. ![]() Protein digestion in the stomach takes a longer time than carbohydrate digestion, but a shorter time than fat digestion. The powerful mechanical stomach contractions churn the partially digested protein into a more uniform mixture called chyme. Egg proteins are large globular molecules and their chemical breakdown requires time and mixing. Pepsin, which is secreted by the cells that line the stomach, dismantles the protein chains into smaller and smaller fragments. The acidity of the stomach facilitates the unfolding of the proteins that still retain part of their three-dimensional structure after cooking and helps break down the protein aggregates formed during cooking. The stomach releases gastric juices containing hydrochloric acid and the enzyme, pepsin, which initiate the breakdown of the protein. The mashed egg pieces enter the stomach through the esophageal sphincter. The salivary glands provide some saliva to aid swallowing and the passage of the partially mashed egg through the esophagus. The teeth begin the mechanical breakdown of the large egg pieces into smaller pieces that can be swallowed. ![]() Unless you are eating it raw, the first step in egg digestion (or any other protein food) involves chewing. Image by Allison Calabrese / CC BY 4.0 From the Mouth to the Stomach One egg, whether raw, hard-boiled, scrambled, or fried, supplies about six grams of protein.įigure 6.7 Digestion and Absorption of Protein Eggs are a good dietary source of protein and will be used as our example to describe the path of proteins in the processes of digestion and absorption. We previously discussed the general process of food digestion, let’s follow the specific path that proteins take down the gastrointestinal tract and into the circulatory system (Figure 6.7 “Digestion and Absorption of Protein”). How do the proteins from foods, denatured or not, get processed into amino acids that cells can use to make new proteins? When you eat food the body’s digestive system breaks down the protein into the individual amino acids, which are absorbed and used by cells to build other proteins and a few other macromolecules, such as DNA. ![]()
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